The nearest humans to this ocean point are usually astronauts overhead

Point Nemo, in the South Pacific, is the spot on Earth's oceans farthest from any land, about 2,688 km from the nearest coastline in every direction. Because it's so remote, space agencies use the surrounding waters as a 'spacecraft cemetery' for decommissioned satellites, meaning the closest people to Point Nemo are often the crew of the International Space Station passing 400km overhead.

— Hrvoje Lukatela, Point Nemo — Coordinates calculated using custom geospatial software, 1992